Controlling Surface-Induced Platelet Activation by Agarose and Gelatin-Based Hydrogel Films.

ABSTRACT: Platelet-surface interaction is of paramount importance in biomedical applications as well as in vitro studies. However, controlling platelet-surface activation is challenging and still requires more effort as they activate immediately when contacting with any nonphysiological surface. As hydrogels are highly biocompatible, in this study, we developed agarose and gelatin-based hydrogel films to inhibit platelet-surface adhesion. We found promising agarose films that exhibit higher surface wettability, better controlled-swelling properties, and greater stiffness compared to gelatin, resulting in a strong reduction of platelet adhesion. Mechanical properties and surface wettability of the hydrogel films were varied by adding magnetite (Fe₃O₄) nanoparticles. While all of

SUBMITTER: Apte G 

PROVIDER: S-EPMC8153948 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature