Encapsulation of Curcumin in Polystyrene-Based Nanoparticles-Drug Loading Capacity and Cytotoxicity.

ABSTRACT: Nanoparticles made of amphiphilic block copolymers are commonly used in the preparation of nano-sized drug delivery systems. Poly(styrene)-block -poly(acrylic acid) (PS-PAA) copolymers have been proposed for drug delivery purposes; however, the drug loading capacity and cytotoxicity of PS-PAA nanoparticles are still not fully recognized. Herein, we investigated the accumulation of a model hydrophobic drug, curcumin, and its spatial distribution inside the PS-PAA nanoparticles. Experimental methods and atomistic molecular dynamics simulations were used to understand the molecular structure of the PS core and how curcumin molecules interact and organize within the PS matrix. The hydrophobic core of the PS-PAA nanoparticles consists of adhering individually coiled polymeric chai

SUBMITTER: Zatorska-Plachta M 

PROVIDER: S-EPMC8154162 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature