Lipidomic Network of Mild Cognitive Impairment from the Mayo Clinic Study of Aging.

ABSTRACT:

Background

Lipid alterations contribute to Alzheimer's disease (AD) pathogenesis. Lipidomics studies could help systematically characterize such alterations and identify potential biomarkers.

Objective

To identify lipids associated with mild cognitive impairment and amyloid-β deposition, and to examine lipid correlation patterns within phenotype groupsMethods:Eighty plasma lipids were measured using mass spectrometry for 1,255 non-demented participants enrolled in the Mayo Clinic Study of Aging. Individual lipids associated with mild cognitive impairment (MCI) were first identified. Correlation network analysis was then performed to identify lipid species with stable correlations across conditions. Finally, differential correlation network analysis was used to determine lipi

SUBMITTER: Wang X 

PROVIDER: S-EPMC8154710 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature