Phosphorylated tau targeted small-molecule PROTACs for the treatment of Alzheimer's disease and tauopathies.

ABSTRACT: Tau is a microtubule-stabilizing protein that plays an important role in the formation of axonal microtubules in neurons. Phosphorylated tau (p-Tau) has received great attention in the field of Alzheimer's disease (AD) as a potential therapeutic target due to its involvement with synaptic damage and neuronal dysfunction. Mounting evidence suggests that amyloid beta (Aβ)-targeted clinical trials continuously failed; therefore, it is important to consider alternative therapeutic strategies such as p-tau-PROTACs targeted small molecules for AD and other tauopathies. The present article describes the characteristics of tau biology, structure, and function in both healthy and pathological states in AD. It also explains data from studies that have identified the involvement of p-tau in neuronal

SUBMITTER: Jangampalli Adi P 

PROVIDER: S-EPMC8154736 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature