Validation of multiparametric MRI by histopathology after nephrectomy: a case study.

ABSTRACT:

Objectives

Renal multiparametric MRI (mpMRI) is a promising tool to monitor renal allograft health to enable timely treatment of chronic allograft nephropathy. This study aims to validate mpMRI by whole-kidney histology following transplantectomy.

Materials and methods

A patient with kidney transplant failure underwent mpMRI prior to transplantectomy. The mpMRI included blood oxygenation level-dependent (BOLD) MRI, T₁ and T₂ mapping, diffusion-weighted imaging (DWI), 2D phase contrast (2DPC) and arterial spin labeling (ASL). Parenchymal mpMRI measures were compared to normative values obtained in 19 healthy controls. Differences were expressed in standard deviations (SD) of normative values. The mpMRI measures were compared qualitatively to histology.

SUBMITTER: de Boer A 

PROVIDER: S-EPMC8154819 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature