Hydrated Ionic Liquids Boost the Trace Detection Capacity of Proteins on TiO₂ Support.

ABSTRACT: Trace detection based on surface-enhanced Raman scattering (SERS) has attracted considerable attention, and exploiting efficient strategies to stretch the limit of detection and understanding the mechanisms on molecular level are of utmost importance. In this work, we use ionic liquids (ILs) as trace additives in a protein-TiO₂ system, allowing us to obtain an exceptionally low limit of detection down to 10^-9 M. The enhancement factors (EFs) were determined to 2.30 × 10⁴, 6.17 × 10⁴, and 1.19 × 10⁵, for the three systems: one without ILs, one with ILs in solutions, and one with ILs immobilized on the TiO₂ substrate, respectively, corresponding to the molecular forces of 1.65, 1.32, and 1.16 nN quantified by the atomic force

SUBMITTER: Dong Y 

PROVIDER: S-EPMC8154861 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature