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Explaining deep neural networks for knowledge discovery in electrocardiogram analysis.

ABSTRACT: Deep learning-based tools may annotate and interpret medical data more quickly, consistently, and accurately than medical doctors. However, as medical doctors are ultimately responsible for clinical decision-making, any deep learning-based prediction should be accompanied by an explanation that a human can understand. We present an approach called electrocardiogram gradient class activation map (ECGradCAM), which is used to generate attention maps and explain the reasoning behind deep learning-based decision-making in ECG analysis. Attention maps may be used in the clinic to aid diagnosis, discover new medical knowledge, and identify novel features and characteristics of medical tests. In this paper, we showcase how ECGradCAM attention maps can unmask how a novel deep learning model measures both amplitudes and intervals in 12-lead electrocardiograms, and we show an example of how attention maps may be used to develop novel ECG features.

SUBMITTER: Hicks SA

PROVIDER: S-EPMC8154909 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Explaining deep neural networks for knowledge discovery in electrocardiogram analysis.

Hicks Steven A SA Isaksen Jonas L JL Thambawita Vajira V Ghouse Jonas J Ahlberg Gustav G Linneberg Allan A Grarup Niels N Strümke Inga I Ellervik Christina C Olesen Morten Salling MS Hansen Torben T Graff Claus C Holstein-Rathlou Niels-Henrik NH Halvorsen Pål P Maleckar Mary M MM Riegler Michael A MA Kanters Jørgen K JK

Scientific reports 20210526 1

Deep learning-based tools may annotate and interpret medical data more quickly, consistently, and accurately than medical doctors. However, as medical doctors are ultimately responsible for clinical decision-making, any deep learning-based prediction should be accompanied by an explanation that a human can understand. We present an approach called electrocardiogram gradient class activation map (ECGradCAM), which is used to generate attention maps and explain the reasoning behind deep learning-b ...[more]

PMID: 34040033

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Dataset Information

Explaining deep neural networks for knowledge discovery in electrocardiogram analysis.

Publications

Explaining deep neural networks for knowledge discovery in electrocardiogram analysis.

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