Understanding T cell phenotype for the design of effective chimeric antigen receptor T cell therapies.

ABSTRACT: Rapid advances in immunotherapy have identified adoptive cell transfer as one of the most promising approaches for the treatment of cancers. Large numbers of cancer reactive T lymphocytes can be generated ex vivo from patient blood by genetic modification to express chimeric antigen receptors (CAR) specific for tumor-associated antigens. CAR T cells can respond strongly against cancer cells, and adoptive transferred CAR T cells can induce dramatic responses against certain types of cancers. The ability of T cells to respond against disease depends on their ability to localize to sites, persist and exert functions, often in an immunosuppressive microenvironment, and these abilities are reflected in their phenotypes. There is currently intense interest in generating CAR T cells possessing th

SUBMITTER: Tantalo DG 

PROVIDER: S-EPMC8154965 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature