Ontology highlight
ABSTRACT:
SUBMITTER: Zhong W
PROVIDER: S-EPMC8155027 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Zhong Wenhui W Liu Heping H Deng Li L Chen Guohua G Liu Yubin Y
Cell death & disease 20210526 6
Hepatocellular carcinoma (HCC) is a common primary liver malignancy lacking effective molecularly-targeted therapies. HBO1 (lysine acetyltransferase 7/KAT7) is a member of MYST histone acetyltransferase family. Its expression and potential function in HCC are studied. We show that HBO1 mRNA and protein expression is elevated in human HCC tissues and HCC cells. HBO1 expression is however low in cancer-surrounding normal liver tissues and hepatocytes. In HepG2 and primary human HCC cells, shRNA-in ...[more]