Ontology highlight
ABSTRACT:
SUBMITTER: Cooper JA
PROVIDER: S-EPMC8155144 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Cooper Jessica A JA Nuutinen Makiah R MR Lawlor Victoria M VM DeVries Brittany A M BAM Barrick Elyssa M EM Hossein Shabnam S Cole Daniel J DJ Leonard Chelsea V CV Hahn Evan C EC Teer Andrew P AP Shields Grant S GS Slavich George M GM Ongur Dost D Jensen J Eric JE Du Fei F Pizzagalli Diego A DA Treadway Michael T MT
Nature communications 20210526 1
Stress is a significant risk factor for the development of major depressive disorder (MDD), yet the underlying mechanisms remain unclear. Preclinically, adaptive and maladaptive stress-induced changes in glutamatergic function have been observed in the medial prefrontal cortex (mPFC). Here, we examine stress-induced changes in human mPFC glutamate using magnetic resonance spectroscopy (MRS) in two healthy control samples and a third sample of unmedicated participants with MDD who completed the M ...[more]