Effects of intranasal guanosine administration on brain function in a rat model of ischemic stroke.

ABSTRACT: Ischemic stroke is a major cause of morbidity and mortality worldwide and only few affected patients are able to receive treatment, especially in developing countries. Detailed pathophysiology of brain ischemia has been extensively studied in order to discover new treatments with a broad therapeutic window and that are accessible to patients worldwide. The nucleoside guanosine (Guo) has been shown to have neuroprotective effects in animal models of brain diseases, including ischemic stroke. In a rat model of focal permanent ischemia, systemic administration of Guo was effective only when administered immediately after stroke induction. In contrast, intranasal administration of Guo (In-Guo) was effective even when the first administration was 3 h after stroke induction. In order to validate

SUBMITTER: Muller GC 

PROVIDER: S-EPMC8155160 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature