Glyconanofluorides as Immunotracers with a Tunable Core Composition for Sensitive Hotspot Magnetic Resonance Imaging of Inflammatory Activity.

ABSTRACT: Nature-inspired nanosized formulations based on an imageable, small-sized inorganic core scaffold, on which biomolecules are assembled to form nanobiomimetics, hold great promise for both early diagnostics and developed therapeutics. Nevertheless, the fabrication of nanobiomimetics that allow noninvasive background-free mapping of pathological events with improved sensitivity, enhanced specificity, and multiplexed capabilities remains a major challenge. Here, we introduce paramagnetic glyconanofluorides as small-sized (<10 nm) glycomimetics for immunotargeting and sensitive noninvasive in vivo ¹⁹F magnetic resonance imaging (MRI) mapping of inflammation. A very short T₁ relaxation time (70 ms) of the fluorides was achieved by doping the nanofluorides' so

SUBMITTER: Cohen D 

PROVIDER: S-EPMC8155386 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature