Signatures of Discriminative Copy Number Aberrations in 31 Cancer Subtypes.

ABSTRACT: Copy number aberrations (CNA) are one of the most important classes of genomic mutations related to oncogenetic effects. In the past three decades, a vast amount of CNA data has been generated by molecular-cytogenetic and genome sequencing based methods. While this data has been instrumental in the identification of cancer-related genes and promoted research into the relation between CNA and histo-pathologically defined cancer types, the heterogeneity of source data and derived CNV profiles pose great challenges for data integration and comparative analysis. Furthermore, a majority of existing studies have been focused on the association of CNA to pre-selected "driver" genes with limited application to rare drivers and other genomic elements. In this study, we developed a bioinformatics pi

SUBMITTER: Gao B 

PROVIDER: S-EPMC8155688 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature