A Genome-Wide Association Study for Hypertensive Kidney Disease in Korean Men.

ABSTRACT: Hypertension is one of the major risk factors for chronic kidney disease (CKD), and the coexistence of hypertension and CKD increases morbidity and mortality. Although many genetic factors have been identified separately for hypertension and kidney disease, studies specifically focused on hypertensive kidney disease (HKD) have been rare. Therefore, this study aimed to identify loci or genes associated with HKD. A genome-wide association study (GWAS) was conducted using two Korean cohorts, the Health Examinee (HEXA) and Korean Association REsource (KARE). Consequently, 19 single nucleotide polymorphisms (SNPs) were found to be significantly associated with HKD in the discovery and replication phases (p < 5 × 10^-8, p < 0.05, respectively). We further analyzed HKD-rel

SUBMITTER: Kim HR 

PROVIDER: S-EPMC8155956 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature