Nucleic Acid Delivery with Red-Blood-Cell-Based Carriers.

ABSTRACT: Gene therapy has the potential to become a staple of 21st-century medicine. However, to overcome the limitations of existing gene-delivery therapies, that is, poor stability and inefficient and delivery and accumulation of nucleic acids (NAs), safe drug-delivery systems (DDSs) allowing the prolonged circulation and expression of the administered genes in vivo are needed. In this review article, the development of DDSs over the past 70 years is briefly described. Since synthetic DDSs can be recognized and eliminated as foreign substances by the immune system, new approaches must be found. Using the body's own cells as DDSs is a unique and exciting strategy and can be used in a completely new way to overcome the critical limitations of existing drug-delivery approaches. Among the different c

SUBMITTER: Della Pelle G 

PROVIDER: S-EPMC8156122 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature