Effect of 2 Inactivated SARS-CoV-2 Vaccines on Symptomatic COVID-19 Infection in Adults: A Randomized Clinical Trial.

ABSTRACT:

Importance

Although effective vaccines against COVID-19 have been developed, additional vaccines are still needed.

Objective

To evaluate the efficacy and adverse events of 2 inactivated COVID-19 vaccines.

Design, setting, and participants

Prespecified interim analysis of an ongoing randomized, double-blind, phase 3 trial in the United Arab Emirates and Bahrain among adults 18 years and older without known history of COVID-19. Study enrollment began on July 16, 2020. Data sets used for the interim analysis of efficacy and adverse events were locked on December 20, 2020, and December 31, 2020, respectively.

Interventions

Participants were randomized to receive 1 of 2 inactivated vaccines developed from SARS-CoV-2 WIV04 (5 µg/dose; n = 13 459) and HB02 (4 µg/dose;

SUBMITTER: Al Kaabi N 

PROVIDER: S-EPMC8156175 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature