Granulomatous Dermatitis Associated With Rubella Virus Infection in an Adult With Immunodeficiency.

ABSTRACT:

Importance

Immunodeficiency-related, vaccine-derived rubella virus (RuV) as an antigenic trigger of cutaneous and visceral granulomas is a rare, recently described phenomenon in children and young adults treated with immunosuppressant agents.

Objective

To perform a comprehensive clinical, histologic, immunologic, molecular, and genomic evaluation to elucidate the potential cause of an adult patient's atypical cutaneous granulomas.

Design, setting, and participants

A prospective evaluation of skin biopsies, nasopharyngeal swabs, and serum samples submitted to the Centers for Disease Control and Prevention was conducted to assess for RuV using real-time reverse-transcriptase polymerase chain reaction (RT-PCR) and viral genomic sequencing. The samples were obtained from

SUBMITTER: Shields BE 

PROVIDER: S-EPMC8156178 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature