Genetically Proxied Diurnal Preference, Sleep Timing, and Risk of Major Depressive Disorder.

ABSTRACT:

Importance

Morning diurnal preference is associated with reduced risk of major depressive disorder (MDD); however, causality in this association is uncertain.

Objective

To examine the association of genetically proxied morning diurnal preference with depression risk using mendelian randomization.

Design, setting, and participants

This 2-sample mendelian randomization study used summary-level genetic associations with diurnal preference and MDD. Up to 340 genetic loci associated with diurnal preference in a meta-analysis of the UK Biobank and 23andMe cohorts were considered as genetic proxies for diurnal preference. The effect size of these variants was scaled using genetic associations with accelerometer-based measurement of sleep midpoint. Genetic associations with M

SUBMITTER: Daghlas I 

PROVIDER: S-EPMC8156187 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature