Heterogeneity of Colorectal Cancer Progression: Molecular Gas and Brakes.

ABSTRACT: The review begins with molecular genetics, which hit the field unveiling the involvement of oncogenes and tumor suppressor genes in the pathogenesis of colorectal cancer (CRC) and uncovering genetic predispositions. Then the notion of molecular phenotypes with different clinical behaviors was introduced and translated in the clinical arena, paving the way to next-generation sequencing that captured previously unrecognized heterogeneity. Among other molecular regulators of CRC progression, the extent of host immune response within the tumor micro-environment has a critical position. Translational sciences deeply investigated the field, accelerating the pace toward clinical transition, due to its strong association with outcomes. While the perturbation of gut homeostasis occurring in inflamm

SUBMITTER: Gaiani F 

PROVIDER: S-EPMC8156342 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature