Differential Spatio-Temporal Regulation of T-Box Gene Expression by microRNAs during Cardiac Development.

ABSTRACT: Cardiovascular development is a complex process that starts with the formation of symmetrically located precardiac mesodermal precursors soon after gastrulation and is completed with the formation of a four-chambered heart with distinct inlet and outlet connections. Multiple transcriptional inputs are required to provide adequate regional identity to the forming atrial and ventricular chambers as well as their flanking regions; i.e., inflow tract, atrioventricular canal, and outflow tract. In this context, regional chamber identity is widely governed by regional activation of distinct T-box family members. Over the last decade, novel layers of gene regulatory mechanisms have been discovered with the identification of non-coding RNAs. microRNAs represent the most well-studied subcategory am

SUBMITTER: Alzein M 

PROVIDER: S-EPMC8156480 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature