Correlating Genotyping Data of Coxiella burnetii with Genomic Groups.

ABSTRACT: Coxiella burnetii is a zoonotic pathogen that resides in wild and domesticated animals across the globe and causes a febrile illness, Q fever, in humans. Several distinct genetic lineages or genomic groups have been shown to exist, with evidence for different virulence potential of these lineages. Multispacer Sequence Typing (MST) and Multiple-Locus Variable number tandem repeat Analysis (MLVA) are being used to genotype strains. However, it is unclear how these typing schemes correlate with each other or with the classification into different genomic groups. Here, we created extensive databases for published MLVA and MST genotypes of C. burnetii and analysed the associated metadata, revealing associations between animal host and human disease type. We established a new classification sche

SUBMITTER: Hemsley CM 

PROVIDER: S-EPMC8156542 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature