Stability across the Whole Nuclear Genome in the Presence and Absence of DNA Mismatch Repair.

ABSTRACT: We describe the contribution of DNA mismatch repair (MMR) to the stability of the eukaryotic nuclear genome as determined by whole-genome sequencing. To date, wild-type nuclear genome mutation rates are known for over 40 eukaryotic species, while measurements in mismatch repair-defective organisms are fewer in number and are concentrated on Saccharomyces cerevisiae and human tumors. Well-studied organisms include Drosophila melanogaster and Mus musculus, while less genetically tractable species include great apes and long-lived trees. A variety of techniques have been developed to gather mutation rates, either per generation or per cell division. Generational rates are described through whole-organism mutation accumulation experiments and through offspring-parent sequencing, or they have b

SUBMITTER: Lujan SA 

PROVIDER: S-EPMC8156620 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature