Biosynthesis of Nature-Inspired Unnatural Cannabinoids.

ABSTRACT: Natural products make up a large proportion of medicine available today. Cannabinoids from the plant Cannabis sativa is one unique class of meroterpenoids that have shown a wide range of bioactivities and recently seen significant developments in their status as therapeutic agents for various indications. Their complex chemical structures make it difficult to chemically synthesize them in efficient yields. Synthetic biology has presented a solution to this through metabolic engineering in heterologous hosts. Through genetic manipulation, rare phytocannabinoids that are produced in low yields in the plant can now be synthesized in larger quantities for therapeutic and commercial use. Additionally, an exciting avenue of exploring new chemical spaces is made available as novel derivatized com

SUBMITTER: Lim KJH 

PROVIDER: S-EPMC8156804 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature