The TRPA1 Agonist Cinnamaldehyde Induces the Secretion of HCO₃^- by the Porcine Colon.

ABSTRACT: A therapeutic potential of the TRPA1 channel agonist cinnamaldehyde for use in inflammatory bowel disease is emerging, but the mechanisms are unclear. Semi-quantitative qPCR of various parts of the porcine gastrointestinal tract showed that mRNA for TRPA1 was highest in the colonic mucosa. In Ussing chambers, 1 mmol·L^-1 cinnamaldehyde induced increases in short circuit current (ΔI_sc) and conductance (ΔG_t) across the colon that were higher than those across the jejunum or after 1 mmol·L^-1 thymol. Lidocaine, amiloride or bumetanide did not change the response. The application of 1 mmol·L^-1 quinidine or the bilateral replacement of 120 Na⁺, 120 Cl^- or 25 HCO₃^- reduced ΔG_t, while the r

SUBMITTER: Manneck D 

PROVIDER: S-EPMC8156935 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature