The Polygenic Nature and Complex Genetic Architecture of Specific Learning Disorder.

ABSTRACT: Specific Learning Disorder (SLD) is a multifactorial, neurodevelopmental disorder which may involve persistent difficulties in reading (dyslexia), written expression and/or mathematics. Dyslexia is characterized by difficulties with speed and accuracy of word reading, deficient decoding abilities, and poor spelling. Several studies from different, but complementary, scientific disciplines have investigated possible causal/risk factors for SLD. Biological, neurological, hereditary, cognitive, linguistic-phonological, developmental and environmental factors have been incriminated. Despite worldwide agreement that SLD is highly heritable, its exact biological basis remains elusive. We herein present: (a) an update of studies that have shaped our current knowledge on the disorder's genetic arc

SUBMITTER: Georgitsi M 

PROVIDER: S-EPMC8156942 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature