Glycogen synthase kinase (GSK) 3 in pregnancy and parturition: a systematic review of literature.

ABSTRACT: Introduction: Multiple factors and pathways have been reported as critical machineries for cell differentiation and survival during pregnancy; a number of them involve glycogen synthase kinase (GSK) 3a/β. Several reports on GSK3's functional role exist; however, the specific role of GSK3 in reproductive tissues and its contribution to normal or abnormal parturition are still unclear. To fill this knowledge gap, a systematic review of literature was conducted to better understand the functional role of GSK3 in various intrauterine tissues during implantation, pregnancy, and parturition.Methods: We conducted a systematic review of literature on GSK3's expression and function reported between 1980 and 2017 in reproductive tissues during pregnancy using three electronic databases

SUBMITTER: Lavu N 

PROVIDER: S-EPMC8156965 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature