Timing of glioblastoma surgery and patient outcomes: a multicenter cohort study.

ABSTRACT:

Background

The impact of time-to-surgery on clinical outcome for patients with glioblastoma has not been determined. Any delay in treatment is perceived as detrimental, but guidelines do not specify acceptable timings. In this study, we relate the time to glioblastoma surgery with the extent of resection and residual tumor volume, performance change, and survival, and we explore the identification of patients for urgent surgery.

Methods

Adults with first-time surgery in 2012-2013 treated by 12 neuro-oncological teams were included in this study. We defined time-to-surgery as the number of days between the diagnostic MR scan and surgery. The relation between time-to-surgery and patient and tumor characteristics was explored in time-to-event analysis and proportional hazard mo

SUBMITTER: Muller DMJ 

PROVIDER: S-EPMC8156977 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature