Antibacterial Porous Coaxial Drug-Carrying Nanofibers for Sustained Drug-Releasing Applications.

ABSTRACT: The phenomenon of drug burst release is the main problem in the field of drug delivery systems, as it means that a good therapeutic effect cannot be acheived. Nanofibers developed by electrospinning technology have large specific surface areas, high porosity, and easily controlled morphology. They are being considered as potential carriers for sustained drug release. In this paper, we obtained polycaprolactone (PCL)/polylactic acid (PLA) core-shell porous drug-carrying nanofibers by using coaxial electrospinning technology and the nonsolvent-induced phase separation method. Roxithromycin (ROX), a kind of antibacterial agent, was encapsulated in the core layer. The morphology, composition, and thermal properties of the resultant nanofibers were characterized by scanning electron microscopy

SUBMITTER: Chen X 

PROVIDER: S-EPMC8157037 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature