SARS-Cov2 S Protein Features Potential Estrogen Binding Site.

ABSTRACT:

Research background

During the current SARS-CoV2 pandemic, as well as earlier SARS and MERS epidemics, it has been observed that COVID19-positive women on average tend to have milder symptoms and lower fatality rates than men. There is a number of differences between the sexes known to contribute to different immune responses and severity of the disease, one being the effect of estrogen via estrogen receptor signalling. We wondered if estrogen might also affect the SARS-CoV2 more directly, perhaps by binding to the surface glycoprotein (S protein), thus possibly reducing its infectivity.

Experimental approach

To assess whether there is a possibility for estrogen binding on the SARS-CoV2 S protein, we used BLAST and HHpred to compare protein sequences of S protein and

SUBMITTER: Tomasovic A 

PROVIDER: S-EPMC8157085 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature