Family-Based Genome-Wide Association Study of Autism Spectrum Disorder in Middle Eastern Families.

ABSTRACT: Autism spectrum disorder (ASD) is a neurodevelopmental disease characterized by abnormalities in language and social communication with substantial clinical heterogeneity. Genetic factors play an important role in ASD with heritability estimated between 70% to 80%. Genome-wide association studies (GWAS) have identified multiple loci associated with ASD. However, most studies were performed on European populations and little is known about the genetic architecture of ASD in Middle Eastern populations. Here, we report the first GWAS of ASD in the Middle eastern population of Qatar. We analyzed 171 families with ASD, using linear mixed models adjusting for relatedness and other confounders. Results showed that common single nucleotide polymorphisms (SNP) in seven loci are associated with ASD

SUBMITTER: Al-Sarraj Y 

PROVIDER: S-EPMC8157263 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature