Rapid differentiation between bacterial infections and cancer using a near-infrared fluorogenic probe.

ABSTRACT: The reliable differentiation between bacterial infections and other pathologies is crucial for both diagnostics and therapeutic approaches. To accommodate such needs, we herein report the development of an activatable near-infrared fluorescent probe 1 that could be applied in the ultrafast, ultrasensitive and specific detection of nitroreductase (NTR) activity in bacterial pathogens both in vitro and in vivo. Upon reaction with NTR, the nitro-group of the para-nitro phenyl sulfonic moiety present in probe 1 was reduced to an amino-group, resulting in a near-infrared fluorescence turn-on of the latent cyanine 7 fluorophore. Probe 1 was capable of rapid and real-time quantitative detection of 0-150 ng mL^-1 NTR with a limit of detection as

SUBMITTER: Wu LL 

PROVIDER: S-EPMC8157330 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature