Targeted and modular architectural polymers employing bioorthogonal chemistry for quantitative therapeutic delivery.

ABSTRACT: There remain several key challenges to existing therapeutic systems for cancer therapy, such as quantitatively determining the true, tissue-specific drug release profile in vivo, as well as reducing side-effects for an increased standard of care. Hence, it is crucial to engineer new materials that allow for a better understanding of the in vivo pharmacokinetic/pharmacodynamic behaviours of therapeutics. We have expanded on recent "click-to-release" bioorthogonal pro-drug activation of antibody-drug conjugates (ADCs) to develop a modular and controlled theranostic system for quantitatively assessing site-specific drug activation and deposition from a nanocarrier molecule, by employing defined chemistries. The exploitation of quantitative imaging using positron emission tomogra

SUBMITTER: Ediriweera GR 

PROVIDER: S-EPMC8157365 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature