Ontology highlight
ABSTRACT:
SUBMITTER: Ediriweera GR
PROVIDER: S-EPMC8157365 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Ediriweera Gayathri R GR Simpson Joshua D JD Fuchs Adrian V AV Venkatachalam Taracad K TK Van De Walle Matthias M Howard Christopher B CB Mahler Stephen M SM Blinco James P JP Fletcher Nicholas L NL Houston Zachary H ZH Bell Craig A CA Thurecht Kristofer J KJ
Chemical science 20200306 12
There remain several key challenges to existing therapeutic systems for cancer therapy, such as quantitatively determining the true, tissue-specific drug release profile <i>in vivo</i>, as well as reducing side-effects for an increased standard of care. Hence, it is crucial to engineer new materials that allow for a better understanding of the <i>in vivo</i> pharmacokinetic/pharmacodynamic behaviours of therapeutics. We have expanded on recent "click-to-release" bioorthogonal pro-drug activation ...[more]