Overcoming chemotherapy resistance using pH-sensitive hollow MnO₂ nanoshells that target the hypoxic tumor microenvironment of metastasized oral squamous cell carcinoma.

ABSTRACT:

Background

Smart nanoscale drug delivery systems that target acidic tumor microenvironments (TME) could offer controlled release of drugs and modulate the hypoxic TME to enhance cancer therapy. The majority of previously reported MnO₂ nanostructures are nanoparticles, nanosheets, or nanocomposites incorporated with other types of nanoparticles, which may not offer the most effective method for drug loading or for the controlled release of therapeutic payloads. Previous studies have designed MnO₂ nanoshells that achieve tumor-specific and enhanced combination therapy for localized advanced cancer. However, the therapeutic effect of MnO₂ nanoshells on metastatic cancer is still uncertain.

Result

Here, intelligent "theranostic" platforms were sy

SUBMITTER: Zhou ZH 

PROVIDER: S-EPMC8157461 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature