Tackling the chemical diversity of microbial nonulosonic acids - a universal large-scale survey approach.

ABSTRACT: Nonulosonic acids, commonly referred to as sialic acids, are a highly important group of nine-carbon sugars common to all domains of life. They all share biosynthetic and structural features, but otherwise display a remarkable chemical diversity. In humans, sialic acids cover all cells which makes them important for processes such as cellular protection, immunity and brain development. On the other hand, sialic acids and other nonulosonic acids have been associated with pathological processes including cancer and viral infections. In prokaryotes, nonulosonic acids are commonly associated with pathogens, which developed through molecular mimicry a strategy to circumvent the host's immune response. However, the remarkably large chemical diversity of prokaryotic nonulosonic acids challenges t

SUBMITTER: Kleikamp HBC 

PROVIDER: S-EPMC8157484 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature