Platinum(ii) non-covalent crosslinkers for supramolecular DNA hydrogels.

ABSTRACT: Manipulation of non-covalent metal-metal interactions allows the fabrication of functional metallosupramolecular structures with diverse supramolecular behaviors. The majority of reported studies are mostly designed and governed by thermodynamics, with very few examples of metallosupramolecular systems exhibiting intriguing kinetics. Here we report a serendipitous finding of platinum(ii) complexes serving as non-covalent crosslinkers for the fabrication of supramolecular DNA hydrogels. Upon mixing the alkynylplatinum(ii) terpyridine complex with double-stranded DNA in aqueous solution, the platinum(ii) complex molecules are found to first stack into columnar phases by metal-metal and π-π interactions, and then the columnar phases that carry multiple positive charges crosslink the negativel

SUBMITTER: Zhang K 

PROVIDER: S-EPMC8157491 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature