Size and charge dual-transformable mesoporous nanoassemblies for enhanced drug delivery and tumor penetration.

ABSTRACT: A series of biological barriers in a nanoparticle-formulated drug delivery process inevitably result in the current low delivery efficiency, limited tumor penetration and insufficient cellular internalization of drugs. These multiple biological barriers are intimately related to the physicochemical properties of nanoparticles, especially the contradictory demand on size and surface charge for long blood circulation (larger and negative) and deep tumor penetration (smaller) as well as efficient cellular internalization (positive). Herein, we report tumor microenvironment triggered size and charge dual-transformable nanoassemblies. The nanoassembly is realized by immobilizing positive up/downconverting luminescent nanoparticles (U/DCNPs) onto large mesoporous silica nanoparticles (MSNs) v

SUBMITTER: Chen L 

PROVIDER: S-EPMC8157500 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature