CpGmotifs: a tool to discover DNA motifs associated to CpG methylation events.

ABSTRACT:

Background

The investigation of molecular alterations associated with the conservation and variation of DNA methylation in eukaryotes is gaining interest in the biomedical research community. Among the different determinants of methylation stability, the DNA composition of the CpG surrounding regions has been shown to have a crucial role in the maintenance and establishment of methylation statuses. This aspect has been previously characterized in a quantitative manner by inspecting the nucleotidic composition in the region. Research in this field still lacks a qualitative perspective, linked to the identification of certain sequences (or DNA motifs) related to particular DNA methylation phenomena.

Results

Here we present a novel computational strategy based on short DNA moti

SUBMITTER: Scala G 

PROVIDER: S-EPMC8157658 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature