Genetic interaction network has a very limited impact on the evolutionary trajectories in continuous culture-grown populations of yeast.

ABSTRACT:

Background

The impact of genetic interaction networks on evolution is a fundamental issue. Previous studies have demonstrated that the topology of the network is determined by the properties of the cellular machinery. Functionally related genes frequently interact with one another, and they establish modules, e.g., modules of protein complexes and biochemical pathways. In this study, we experimentally tested the hypothesis that compensatory evolutionary modifications, such as mutations and transcriptional changes, occur frequently in genes from perturbed modules of interacting genes.

Results

Using Saccharomyces cerevisiae haploid deletion mutants as a model, we investigated two modules lacking COG7 or NUP133, which are evolutionarily conserved genes with many interactions. W

SUBMITTER: Klim J 

PROVIDER: S-EPMC8157726 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature