Positive selection on two mitochondrial coding genes and adaptation signals in hares (genus Lepus) from China.

ABSTRACT:

Background

Animal mitochondria play a central role in energy production in the cells through the oxidative phosphorylation (OXPHOS) pathway. Recent studies of selection on different mitochondrial OXPHOS genes have revealed the adaptive implications of amino acid changes in these subunits. In hares, climatic variation and/or introgression were suggested to be at the origin of such adaptation. Here we looked for evidence of positive selection in three mitochondrial OXPHOS genes, using tests of selection, protein structure modelling and effects of amino acid substitutions on the protein function and stability. We also used statistical models to test for climate and introgression effects on sites under positive selection.

Results

Our results revealed seven sites under positive s

SUBMITTER: Awadi A 

PROVIDER: S-EPMC8157742 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature