Gestational diabetes mellitus is associated with the neonatal gut microbiota and metabolome.

ABSTRACT:

Background

Gestational diabetes mellitus (GDM) is a metabolic disease that occurs in pregnant women and increases the risk for the development of diabetes. The relationship between GDM and meconium microbiota and metabolome remains incompletely understood.

Methods

Four hundred eighteen mothers (147 women with GDM and 271 normal pregnant women) and their neonates from the GDM Mother and Child Study were included in this study. Meconium microbiota were profiled by 16S rRNA gene sequencing. Meconium and maternal serum metabolome were examined by UPLC-QE.

Results

Microbial communities in meconium were significantly altered in neonates from the GDM mothers. A reduction in alpha diversity was observed in neonates of GDM mothers. At the phylum level, the abundance of Firmicu

SUBMITTER: Chen T 

PROVIDER: S-EPMC8157751 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature