Animal blood in translational research: How to adjust animal blood viscosity to the human standard.

ABSTRACT: Animal blood is used in mock circulations or in forensic bloodstain pattern analysis. Blood viscosity is important in these settings as it determines the driving pressure through biomedical devices and the shape of the bloodstain. However, animal blood can never exactly mimic human blood due to erythrocyte properties differing among species. This results in the species-specific shear thinning behavior of blood suspensions, and it is therefore not enough to adjust the hematocrit of an animal blood sample to mimic the behavior of human blood over the entire range of shear rates that are present in the body. In order to optimize experiments that require animal blood, we need models to adapt the blood samples. We here offer mathematical models derived for each species using a multi linear regr

SUBMITTER: Ecker P 

PROVIDER: S-EPMC8157792 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature