Propionate Fermentative Genes of the Gut Microbiome Decrease in Inflammatory Bowel Disease.

ABSTRACT: Changes in the gut microbiome have been associated with inflammatory bowel disease. A protective role of short chain fatty acids produced by the gut microbiota has been suggested as a causal mechanism. Nevertheless, multi-omic analyses have failed to identify a clear link between changes in specific taxa and disease states. Recently, metagenomic analyses unveiled that gut bacterial species have a previously unappreciated genomic diversity, implying that a geno-centric approach may be better suited to identifying the mechanisms involved. Here, we quantify the abundance of terminal genes in propionate-producing fermentative pathways in the microbiome of a large cohort of healthy subjects and patients with inflammatory bowel disease. The results show that propionate kinases responsible for pr

SUBMITTER: Medina JM 

PROVIDER: S-EPMC8157882 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature