Persulfidation of ATG18a regulates autophagy under ER stress in Arabidopsis.

ABSTRACT: Hydrogen sulfide (H₂S) is an endogenously generated gaseous signaling molecule, which recently has been implicated in autophagy regulation in both plants and mammals through persulfidation of specific targets. Persulfidation has been suggested as the molecular mechanism through which sulfide regulates autophagy in plant cells. ATG18a is a core autophagy component that is required for bulk autophagy and also for reticulophagy during endoplasmic reticulum (ER) stress. In this research, we revealed the role of sulfide in plant ER stress responses as a negative regulator of autophagy. We demonstrate that sulfide regulates ATG18a phospholipid-binding activity by reversible persulfidation at Cys103, and that this modification activates ATG18a binding capacity to specific phospholipids

SUBMITTER: Aroca A 

PROVIDER: S-EPMC8157962 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature