Off-label postpartum use of domperidone in Canada: a multidatabase cohort study.

ABSTRACT:

Background

Trends in off-label postpartum use of domperidone and the impact of safety advisories on its use remain unknown. Our objectives were to describe postpartum use of domperidone in Canada, to evaluate the impact of Health Canada advisories on prescribing patterns, and to describe the association between domperidone use and a composite end point of sudden cardiac death or ventricular tachycardia (VT) among postpartum patients.

Methods

We conducted a multidatabase cohort study involving pregnant patients with live births between 2004 and 2017 using administrative health databases from 5 Canadian provinces (British Columbia, Alberta, Saskatchewan, Manitoba and Ontario). We excluded patients with less than 1 year of prepregnancy database history and with approved indicat

SUBMITTER: Moriello C 

PROVIDER: S-EPMC8157989 | biostudies-literature | 2021 Apr-Jun

REPOSITORIES: biostudies-literature