Responsive Polyesters with Alkene and Carboxylic Acid Side-Groups for Tissue Engineering Applications.

ABSTRACT: Main chain polyesters have been extensively used in the biomedical field. Despite their many advantages, including biocompatibility, biodegradability, and others, these materials are rather inert and lack specific functionalities which will endow them with additional biological and responsive properties. In this work, novel pH-responsive main chain polyesters have been prepared by a conventional condensation polymerization of a vinyl functionalized diol with a diacid chloride, followed by a photo-induced thiol-ene click reaction to attach functional carboxylic acid side-groups along the polymer chains. Two different mercaptocarboxylic acids were employed, allowing to vary the alkyl chain length of the polymer pendant groups. Moreover, the degree of modification, and as a result, the carbox

SUBMITTER: Mountaki SA 

PROVIDER: S-EPMC8158382 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature