MicroRNA Profiles of Maternal and Neonatal Endothelial Progenitor Cells in Preeclampsia.

ABSTRACT: Preeclampsia is associated with an increased cardiovascular morbidity of mother and offspring, thus contributing to a substantial burden in women and children's health. It has been proven that endothelial progenitor cell (EPC) numbers and functional characteristics are impaired in cardiovascular disease and preeclampsia, although causative factors for the latter have remained elusive. MicroRNA (miRNA) modifications are a potential mechanism through which exposure to an altered environment translates into the development of chronic disease. In this study, we examined whether development of preeclampsia corresponds to alterations of miRNAs in maternal- and cord-blood-derived EPC. To test this end, we analyzed maternal and neonatal miRNAs via RNA sequencing from endothelial cells of preeclamp

SUBMITTER: Brodowski L 

PROVIDER: S-EPMC8158476 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature