Real-World Use of Azathioprine Metabolites Changes Clinical Management of Inflammatory Bowel Disease.

ABSTRACT:

Background

Thiopurines such as 6-mercaptopurine and azathioprine have complex metabolism, resulting in significant inter-individual differences in clinical efficacy and risk of drug toxicity, making conventional weight-based dosing inaccurate and potentially unsafe. Therapeutic drug monitoring (TDM) of thiopurine metabolites improves clinical outcomes through dose optimization and toxicity monitoring. Despite evidence for TDM, use is limited, due in part to test availability and awareness. The objectives of this study were twofold: (1) to investigate how thiopurine TDM impacts clinical management of IBD patients and (2) to evaluate proportion of patients outside therapeutic 6TGN levels or exhibiting signs of toxicity.

Methods

Patients who received thiopurine TDM as part of r

SUBMITTER: Wilson L 

PROVIDER: S-EPMC8158651 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature