Xanthones Active against Multidrug Resistance and Virulence Mechanisms of Bacteria.

ABSTRACT: The emergence of multidrug and extensively drug-resistant pathogenic bacteria able to resist to the action of a wide range of antibiotics is becoming a growing problem for public health. The search for new compounds with the potential to help in the reversion of bacterial resistance plays an important role in current medicinal chemistry research. Under this scope, bacterial efflux pumps are responsible for the efflux of antimicrobials, and their inhibition could reverse resistance. In this study, the multidrug resistance reversing activity of a series of xanthones was investigated. Firstly, docking studies were performed in the AcrAB-TolC efflux pump and in a homology model of the NorA pump. Then, the effects of twenty xanthone derivatives on bacterial growth were evaluated in Staphyloc

SUBMITTER: Duraes F 

PROVIDER: S-EPMC8158687 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature