Radical Scavenging Activity of Natural Anthraquinones: a Theoretical Insight.

ABSTRACT: Anthraquinones (ANQs) isolated from Paederia plants are known to have antidiarrheal, antitussive, anthelmintic, analgesic, anti-inflammatory, antihyperlipidemic, antihyperglycaemic, and antimicrobial activities. The antioxidant properties were also noted but not confirmed thus far. In this study, the superoxide and hydroperoxide radical scavenging activities of six ANQs were evaluated using a computational approach. The results suggest that the ANQs exhibit low HOO^• antiradical activity in all environments, including the gas phase (k < 10² M^-1 s^-1). In contrast, the ANQs might exert excellent O₂ ^•- radical scavenging activity, particularly in aqueous solution. The rate constants of the superoxide anion scavengi

SUBMITTER: Trung NQ 

PROVIDER: S-EPMC8158809 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature