Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions.

ABSTRACT: Obesity is an epidemic internationally. While weight loss interventions are efficacious, they are compounded by heterogeneity with regards to clinically relevant metabolic responses. Thus, we sought to identify metabolic biomarkers that are associated with beneficial metabolic changes to weight loss and which distinguish individuals with obesity who would most benefit from a given type of intervention. Liquid chromatography mass spectrometry-based profiling was used to measure 765 metabolites in baseline plasma from three different weight loss studies: WLM (behavioral intervention, N = 443), STRRIDE-PD (exercise intervention, N = 163), and CBD (surgical cohort, N = 125). The primary outcome was percent change in insulin resistance (as measured by the Homeostatic Model Assessment of Insulin

SUBMITTER: Bihlmeyer NA 

PROVIDER: S-EPMC8158886 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature